Extensive laboratory and field experiments were conducted on predators and parasites safety considering its role in organic and integrated crop protection. Results proved that the product provides exceptional safety to insect natural enemies under practical product application rates. Some laboratory negative impacts under high dosage rates were re-verified in field experiments, which proved its safety. One possible explanation for the safety of natural enemies is the fact that natural enemies do not ingest the product and thus live in amity. In fact, the product aids natural enemy augmentation through its debilitating effect on pests and makes them vulnerable to natural enemies. The product formulations are broadly safe to insect natural enemies and highly compatible with organic and integrated crop protection efforts

The product has been extensively tested for honeybee safety under stringent laboratory experiments as well as field evaluations. The product proved to be highly safe through tests conducted on respiratory, contact and oral toxicity tests on honeybees. Field tests also showed that the product does not alter the behaviour and activities of honeybees. This safe feature of the product help growers worldwide to use the product during times of pollination when restrictions apply for conventional and biological chemicals, which are toxic to bees. The product is also known to cure honeybee diseases such as ‘nosemosis’ and ‘varroa mite’ problems based on recently concluded studies. Users are advised to observe local label recommendations.

The product has been extensively screened for a wide range of beneficials. The product proved its safety to earthworms, fish, and soil microorganisms. Recent studies further showed that the product helps control copepod ectoparasites in ornamental and commercial fish cultivation practices. Users are advised to observe local label recommendations.

The product showed additive and synergistic effects when used along with several conventional chemistries across insecticide groups. The enhanced efficacy was attributed to the physiological and and behavioural modulating effects of azadirachtin that predisposes to greater insecticidal activity. A few studies below support the pesticide synergistic / additive effects. Synergistic effects with insecticides is a key advantage of the product as it increases pest spectrum, efficacy and disrupts resistance tendencies. Synergism of the product help manage hard to control pests and enable an IPM approach. Insecticide synergism tests were conducted on limited compounds and therefore growers are recommended to verify synergism with any new compounds.

The product can be used in chemidation in field crops, greenhouses, mushrooms, pot plants and hydroponics. The product is diluted to1 - 10 ppm  azadirachtin concentrations and can be fed through irrigation system or soil drenching. Chemigation helps control all pests; especially aphids, whiteflies sciarids, fungus gnats, shoreflies, leafhoppers, leafminers and thrips. Chemication also helps manage problems such as wireworms, beetles, cut worm, soil grubs and nematodes. Chemigation needs to be repeated 15-30 days depending on pest incidence and crop stage. Users are advised to observe local label recommendations.

The product can be used for tree injections in forests, public and home garden trees. Tree injections are made using micro syringe holes on tree trunks. The recommended use rate is 10-20ml / tree (0.75 oz) using 3-6 microinjection vials depending on tree size. The product is normally absorbed in a few hours depending on the type of tree. Tree injections help manage a wide range of pests including Caterpillars, Leafminers, Beetles, Sawflies, Weevils and Mites, etc.. Users are advised to observe local label recommendations.

Seed treatment of the product provides protection from soil pests besides controlling pests affecting early crops through azadirachtin systemic effects. The recommended seed treatment rate is between 30-60ppm azadirachtin.